Lisa Goehler, PhD

Research Associate Professor of Nursing

• NIH BioSketch

Publications

Journal Articles

Kinser, P., Goehler, L., & Taylor, A.G. (2012). How might yoga help depression? A neurobiological perspective. EXPLORE: The Journal of Science & Healing, 8(2), 118-126.

Maes, M., Berk, M., Goehler, L., Song, C., Anderson, G., Galecki, P., & Leonard, B. (2012). Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Medicine, 10, 66. doi:10.1186/1741-7015-10-66.

Gaykema, R.P.A., & Goehler, L.E. (2011). Ascending caudal medullary catecholamine pathways drive sickness-induced deficits in exploratory behavior: Brain substrates for fatigue?. Brain, Behavior, and Immunity, 25, 443-460.

Kubera, M., Obuchowicz, E., Goehler, L., Brzeszcz, J., & Maes, M. (2011). In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35, 744-759.

Maes, M., Kubera, M., Obuchowiczwa, E., Goehler, L., & Brzeszcz, J. (2011). Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways. Neuroendocrinology Letters, 32(1), 7-24.

Fairchild, K.D., Srinivasan, V., Moorman, J.R., Gaykema, R.P.A., Goehler, L.E. (2010). Pathogen-induced heart rate changes associated with cholinergic nervous system activation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 300, R330-R339.

Taylor, A.G., Goehler, L.E., Galper, D.I., Innes, K.E., Bourguignon, C. (2010). Top-down and bottom-up mechanisms in mind-body medicine: Development of an integrative framework for psychophysiological research. EXPLORE: The Journal of Science & Healing, 6(1), 29-41.

Jallo, N., Bourguignon, C., Taylor, A.G., Ruiz, J., Goehler, L. (2009). Biobehavioral effects of relaxation guided imagery on maternal stress. Advances in Mind-Body Medicine, 24(4), 12-22.

Rose, K.M., Taylor, A.G., Bourguignon, C., Utz, S.W., Goehler, L. (2009). Cranial electrical stimulation: Potential use in reducing sleep and mood disturbances in persons with dementia and their family caregivers. Alzheimer's Care Today, 10(2), 108-114.

Gaykema,R. P.,Park,S. M.,McKibbin,C. R.,Goehler,L. E. (2008). Lipopolysaccharide suppresses activation of the tuberomammillary histaminergic system concomitant with behavior: a novel target of immune-sensory pathways.. Neuroscience, 152(1), 273-287.

Goehler,L. E.,Park,S. M.,Opitz,N.,Lyte,M.,Gaykema,R. P. (2008). Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior.. Brain, Behavior, & Immunity, 22(3), 354-366.

Park,S. M.,Gaykema,R. P.,Goehler,L. E. (2008). How does immune challenge inhibit ingestion of palatable food? Evidence that systemic lipopolysaccharide treatment modulates key nodal points of feeding neurocircuitry. Brain, behavior, and immunity, 22(8), 1160-1172.

Rose,K. M.,Taylor,A. G.,Bourguignon,C.,Utz,S. W.,Goehler,L. E. (2008). Cranial electrical stimulation: potential use in reducing sleep and mood disturbances in persons with dementia and their family caregivers. Family & community health, 31(3), 240-246.

Goehler,L. E.,Lyte,M.,Gaykema,R. P. (2007). Infection-induced viscerosensory signals from the gut enhance anxiety: implications for psychoneuroimmunology. Brain, Behavior, & Immunity, 21(6), 721-726.

Gaykema,R. P.,Balachandran,M. K.,Godbout,J. P.,Johnson,R. W.,Goehler,L. E. (2007). Enhanced neuronal activation in central autonomic network nuclei in aged mice following acute peripheral immune challenge.. Autonomic Neuroscience-Basic & Clinical, 131(1-2), 137-142.

Gaykema,R. P.,Chen,C. C.,Goehler,L. E. (2007). Organization of immune-responsive medullary projections to the bed nucleus of the stria terminalis, central amygdala, and paraventricular nucleus of the hypothalamus: evidence for parallel viscerosensory pathways in the rat brain.. Brain research, 1130(1), 130-145.

Goehler,L. E. (2006). Vagal complexity: substrate for body-mind connections?. Bratislavske lekarske listy, 107(8), 275-276.

Goehler,L. E.,Erisir,A.,Gaykema,R. P. (2006). Neural-immune interface in the rat area postrema.. Neuroscience, 140(4), 1415-1434.

Lyte,M.,Li,W.,Opitz,N.,Gaykema,R. P.,Goehler,L. E. (2006). Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium.. Physiology & Behavior, 89(3), 350-357.

Lyte,M.,Opitz,N.,Goehler,L. E.,Gaykema,R. P.,Overmier,J. B. (2005). Recommended housing conditions and test procedures can interact to obscure a significant experimental effect.. Behavior Research Methods, 37(4), 651-656.

Goehler,L. E.,Gaykema,R. P.,Opitz,N.,Reddaway,R.,Badr,N.,Lyte,M. (2005). Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni.. Brain, Behavior, & Immunity, 19(4), 334-344.

Gaykema,R. P.,Goehler,L. E.,Lyte,M. (2004). Brain response to cecal infection with Campylobacter jejuni: analysis with Fos immunohistochemistry.. Brain, Behavior, & Immunity, 18(3), 238-245.

Marvel,F. A.,Chen,C. C.,Badr,N.,Gaykema,R. P.,Goehler,L. E. (2004). Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei. Brain, Behavior, & Immunity, 18(2), 123-134.

Goehler,L. E.,Gaykema,R. P.,Hansen,M. K.,Kleiner,J. L.,Maier,S. F.,Watkins,L. R. (2001). Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats.. American Journal of Physiology - Regulatory Integrative & Comparative Physiology, 280(5), R1434-9.

Hansen,M. K.,O'Connor,K. A.,Goehler,L. E.,Watkins,L. R.,Maier,S. F. (2001). The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose.. American Journal of Physiology - Regulatory Integrative & Comparative Physiology, 280(4), R929-34.

Van Dam,A. M.,Bol,J. G.,Gaykema,R. P.,Goehler,L. E.,Maier,S. F.,Watkins,L. R.,Tilders,F. J. (2000). Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1beta immunoreactivity in rat brain and pituitary gland.. Neuroscience letters, 285(3), 169-172.

Goehler,L. E.,Gaykema,R. P.,Hansen,M. K.,Anderson,K.,Maier,S. F.,Watkins,L. R. (2000). Vagal immune-to-brain communication: a visceral chemosensory pathway. Autonomic Neuroscience-Basic & Clinical, 85(1-3), 49-59.

Hansen,M. K.,Daniels,S.,Goehler,L. E.,Gaykema,R. P.,Maier,S. F.,Watkins,L. R. (2000). Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever.. Autonomic Neuroscience-Basic & Clinical, 85(1-3), 83-87.

Hansen,M. K.,Nguyen,K. T.,Fleshner,M.,Goehler,L. E.,Gaykema,R. P.,Maier,S. F.,Watkins,L. R. (2000). Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide.. American Journal of Physiology - Regulatory Integrative & Comparative Physiology, 278(2), R331-6.

Gaykema,R. P.,Goehler,L. E.,Hansen,M. K.,Maier,S. F.,Watkins,L. R. (2000). Subdiaphragmatic vagotomy blocks interleukin-1beta-induced fever but does not reduce IL-1beta levels in the circulation.. Autonomic Neuroscience-Basic & Clinical, 85(1-3), 72-77.

Goehler,L. E.,Gaykema,R. P.,Nguyen,K. T.,Lee,J. E.,Tilders,F. J.,Maier,S. F.,Watkins,L. R. (1999). Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?.. Journal of Neuroscience, 19(7), 2799-2806.

Maier,S. F.,Goehler,L. E.,Fleshner,M.,Watkins,L. R. (1998). The role of the vagus nerve in cytokine-to-brain communication. Annals of the New York Academy of Sciences, 840, 289-300.

Fleshner,M.,Goehler,L. E.,Schwartz,B. A.,McGorry,M.,Martin,D.,Maier,S. F.,Watkins,L. R. (1998). Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy.. Journal of neuroimmunology, 86(2), 134-141.

Gaykema,R. P.,Goehler,L. E.,Tilders,F. J.,Bol,J. G.,McGorry,M.,Fleshner,M.,Maier,S. F.,Watkins,L. R. (1998). Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve.. Neuroimmunomodulation, 5(5), 234-240.

Goehler,L. E.,Gaykema,R. P.,Hammack,S. E.,Maier,S. F.,Watkins,L. R. (1998). Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve.. Brain research, 804(2), 306-310.

Fleshner,M.,Silbert,L.,Deak,T.,Goehler,L. E.,Martin,D.,Watkins,L. R.,Maier,S. F. (1997). TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.. Brain research bulletin, 44(6), 701-706.

Goehler,L. E.,Relton,J. K.,Dripps,D.,Kiechle,R.,Tartaglia,N.,Maier,S. F.,Watkins,L. R. (1997). Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication.. Brain research bulletin, 43(3), 357-364.

Milligan,E. D.,McGorry,M. M.,Fleshner,M.,Gaykema,R. P.,Goehler,L. E.,Watkins,L. R.,Maier,S. F. (1997). Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication.. Brain research, 766(1-2), 240-243.

Goehler,L. E.,Sternini,C. (1996). Calcitonin gene-related peptide innervation of the rat hepatobiliary system.. Peptides, 17(2), 209-217.

Goehler,L. E.,Finger,T. E. (1996). Visceral afferent and efferent columns in the spinal cord of the teleost, Ictalurus punctatus.. Journal of Comparative Neurology, 371(3), 437-447.

Watkins,L. R.,Maier,S. F.,Goehler,L. E. (1995). Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sciences, 57(11), 1011-1026.

Watkins,L. R.,Maier,S. F.,Goehler,L. E. (1995). Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain, 63(3), 289-302.

Bernstein,I. L.,Treneer,C. M.,Goehler,L. E.,Murowchick,E. (1985). Tumor growth in rats: conditioned suppression of food intake and preference.. Behavioral neuroscience, 99(5), 818-830.

Bernstein,I. L.,Goehler,L. E.,Fenner,D. P. (1984). Learned aversions to proteins in rats on a dietary self-selection regimen.. Behavioral neuroscience, 98(6), 1065-1072.

Bernstein,I. L.,Goehler,L. E. (1983). Chronic lithium chloride infusions: conditioned suppression of food intake and preference.. Behavioral neuroscience, 97(2), 290-298.

Bernstein,I. L.,Goehler,L. E. (1983). Vagotomy produces learned food aversions in the rat.. Behavioral neuroscience, 97(4), 585-594.

Bernstein,I. L.,Goehler,L. E.,Bouton,M. E. (1983). Relative potency of foods and drinks as targets in aversion conditioning.. Behavioral & Neural Biology, 37(1), 134-148.

Book Sections

Goehler,L. E.,Gaykema,R. P. (2007). Immune Signaling to Brain: mechanisms and potential pathways influencing sleep. In Pandi-Perumal,S. R., Cardinali,D. P.,Chrousos,G. P. (Ed.), Neuroimmunology of sleep (pp. 119-132). New York: Springer Publishing Company